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Finally, dietary carbohydrates, but also polyphenols and PUFA were associated with significant fibrosis on histology only in carriers of the PNPLA3 G-allele (G/C or G/G) [187]

Overall quality of evidence The quality and consistency of each comparison was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines through GRADEpro (Balshem et al

Dot-Blots, xi

Many report a general sense of discomfortstiffness in the lower back, tightness in the hips, tingling in the legsthat may not yet warrant clinical intervention but signals the need for more intentional support